Two different serologic mechanisms of paroxysmal cold hemoglobinuria, illustrated by three cases.
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چکیده
منابع مشابه
Autoimmune hemolytic anemias and paroxysmal nocturnal hemoglobinuria
The hallmark of the autoimmune hemolytic anemias (AIHAs) and paroxysmal nocturnal hemoglobinuria (PNH) is shortened red blood cell survival. Although AIHA and PNH share the critical feature of shortened red cell survival, the mechanisms underlying this characteristic differ significantly between the two diseases. In the case of AIHA, autoantibodies directed against the patient’s own red blood c...
متن کاملSerologic properties of a cold hemolysin and an acid hemolysin occurring in a case of syphilitic paroxysmal cold hemoglobinuria.
By E. T. PETERSON, A.B. AND H. L. WALFORD, M.D. T HE CLINICAL ENTITY of syphilitic paroxysmal cold hemoglohimsuria has beens adequately described by Rosensbach,’ Domsath amid Landsteiner,2 Mackenszie,3 Ross4 amid others. Ins this disease exposure to cold induces a paroxysm characterized by a shakinig chill, fever, flank pain amid hemoglobinuria. This phensomensoni is thought to be due to a cold...
متن کاملCase report: paroxysmal cold hemoglobinuria presenting during pregnancy
BACKGROUND Paroxysmal cold hemoglobinuria is caused by a biphasic IgG autoantibody that triggers complement-mediated intravascular hemolysis. Paroxysmal cold hemoglobinuria has not previously been reported to occur in association with pregnancy. CASE PRESENTATION We report a case of an 18 year old female who presented in early pregnancy with acute hemolytic anemia and a positive Donath-Landst...
متن کاملIdiopathic non-syphilitic paroxysmal cold haemoglobinuria in children.
Three examples of non-syphilitic paroxysmal cold haemoglobinuria (PCH) in children are described which occurred, within a period of 16 days, in association with a febrile illness. No definite viral aetiology or obvious epidemiological association could be established. A Donath-Landsteiner antibody of anti-P specificity was demonstrated in all three patients. The serological aspects of PCH are c...
متن کاملIntestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.Acute abdominal pain is one of the PNH clinical manifestations due to venous thrombosis of intra-abdominal sites including hepatic, portal, mesenteric, and splenic veins.Eculizumaband allogeneic bone marrow transplantation (BMT) arethe only w...
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ورودعنوان ژورنال:
- Blood
دوره 7 12 شماره
صفحات -
تاریخ انتشار 1952